Controlled study of early postoperative parenteral nutrition in children

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Published on: September 20, 2019

V B Marín1, M G Rebollo, C D Castillo-Duran

  • 1INTA, University of Chile, Santiago.

Journal of Pediatric Surgery
|October 3, 1999
PubMed

Insights

Early parenteral nutrition (PN) in pediatric surgical patients significantly improved nitrogen balance and insulin-like growth factor 1 (IGF-I) levels. This early nutritional support enhances anabolic response and recovery after major surgery.

Area of Science:

  • Pediatric Surgery
  • Nutritional Support
  • Metabolic Response

Background:

  • Recent advancements allow modulation of catabolism and anabolism in surgical patients.
  • Nutritional support can enhance immune response and tissue repair processes.

Purpose of the Study:

  • To evaluate the metabolic effects of early parenteral nutrition (PN) in pediatric patients following major surgery.

Main Methods:

  • 63 children (4-14 years) with perforated-suppurative appendicitis were randomized.
  • Study group (n=31) received PN for 5 days starting 24-48h post-op.
  • Control group (n=32) received standard fluid therapy. Parameters measured: weight, CRP, albumin, prealbumin, glycemia, nitrogen balance (NB), and IGF-I on days 1, 4, and 6.

Main Results:

  • Early PN significantly improved nitrogen balance (NB) (P<.01).
  • Early PN led to a significant increase in insulin-like growth factor 1 (IGF-I) levels (P<.001).

Conclusions:

  • Early parenteral nutrition positively impacts the anabolic response in pediatric surgical patients.
  • Improved NB and higher IGF-I levels indicate enhanced recovery with early PN.
Abstract

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