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Im-trityl protection of histidine
S J Harding1, J H Jones, A N Sabirov
1The Dyson Perrins Laboratory, University of Oxford, UK.
Abstract:
A rational attempt to prepare FmocHis(piTrt)OH regiospecifically gave in fact the well-known tau-trityl isomer, and experiments with model systems indicate that the prospects for access to pi-trityl histidine derivatives, which would be of great value for the racemization-free synthesis of histidine-containing peptides, are poor.