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Related Experiment Videos

Structural genomics: beyond the human genome project.

S K Burley1, S C Almo, J B Bonanno

  • 1Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10021, USA. burley@rockvax.rockefeller.edu

Nature Genetics
|October 3, 1999
PubMed
Summary
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Structural genomics uses high-throughput X-ray crystallography to understand human and microbial physiology. This approach, driven by whole genome sequencing, aims to mechanistically decipher complex biological processes at the molecular level.

Area of Science:

  • Molecular and Cellular Biology
  • Structural Biology
  • Genomics

Background:

  • Advancements in whole genome sequencing and the Human Genome Project are transforming biological discovery.
  • Massively parallel measurement strategies offer new ways to study complex biochemical pathways.
  • An information explosion necessitates new approaches for understanding physiology and disease.

Purpose of the Study:

  • To establish a structural genomics initiative for comprehensive molecular-level understanding.
  • To investigate normal and abnormal human and microbial physiology.
  • To lay the groundwork for high-throughput X-ray crystallography.

Main Methods:

  • High-throughput X-ray crystallography.
  • Analysis of whole genome sequences.

Related Experiment Videos

  • Development of massively parallel measurement strategies.

    • Main Results:

    • The study presents the rationale and ongoing efforts of structural genomics pilot studies.
    • Details are provided on the goals, technical challenges, and potential pitfalls.
    • The foundation for a new structural biology initiative is established.

    Conclusions:

    • Structural genomics, utilizing high-throughput crystallography, is essential for mechanistic understanding of physiology.
    • Genome-wide data fuels a new era of molecular-level biological investigation.
    • Addressing technical challenges is crucial for the success of structural biology initiatives.