Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolution of protein function, from a structural perspective.

A E Todd1, C A Orengo, J M Thornton

  • 1Biomolecular Structure and Modelling Unit Department of Biochemistry and Molecular Biology, University College London, Gower Street, London,WC1E 6BT, UK.

Current Opinion in Chemical Biology
|October 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme-ligand complexes.

Journal of cheminformatics·2024
Same author

Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection.

Prostaglandins & other lipid mediators·2022
Same author

Lipoxin A4 promotes reduction and antibiotic efficacy against Pseudomonas aeruginosa biofilm.

Prostaglandins & other lipid mediators·2020
Same author

SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals.

Scientific reports·2020
Same author

Clinical management of Brucella suis infection in dogs and implications for public health.

Australian veterinary journal·2017
Same author

Modeling birds on wires.

Journal of theoretical biology·2016
Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026
Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026
Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026
Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026
Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026
Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026
See all related articles

Protein structural data reveals enzyme versatility through mutations and domain changes. Understanding these evolutionary adaptations is crucial for accurate genome annotation.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Genomics

Background:

  • Recent advancements in structural data analysis highlight the extensive versatility of protein families.
  • Enzymes exhibit diverse substrate specificities and catalytic activities, often accommodated by local active-site mutations, surface loop variations, and domain recruitment.
  • Evolutionary processes have led to multiple independent structural solutions for similar functions and the emergence of multi-functional genes via gene recruitment.

Purpose of the Study:

  • To analyze the structural and functional versatility of protein families, particularly enzymes.
  • To understand how variations in protein structure contribute to diverse enzymatic functions.
  • To emphasize the importance of considering evolutionary phenomena in genome annotation.

Main Methods:

Related Experiment Videos

  • Analysis of existing structural data for protein families.
  • Comparative analysis of enzyme active sites, surface loops, and domain architectures.
  • Review of evolutionary mechanisms driving protein function diversification.

Main Results:

  • Structural data confirms significant versatility within protein families, especially enzymes.
  • Local mutations, loop variations, and domain additions explain diverse substrate specificities and catalytic activities.
  • Convergent evolution has resulted in multiple structural solutions for certain functions.

Conclusions:

  • The structural plasticity of proteins, particularly enzymes, is a key driver of functional diversity.
  • Evolutionary events like gene recruitment contribute to the complexity of protein families and multi-functional genes.
  • Accurate genome annotation requires consideration of these structural and evolutionary phenomena.