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Updated: Aug 13, 2026

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells
Published on: December 29, 2012
APC: the plot thickens
1Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. mb2@mrc-lmb.cam.ac.uk.
Abstract:
Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.
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