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Streptococcal sore throat in general practice--a controlled study.

B J Feery, P Forsell, M Gulasekharam

    The Medical Journal of Australia
    |June 26, 1976
    PubMed
    Summary
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    Group A haemolytic streptococci were more common in acute tonsillitis patients than controls. Other bacteria and acute pharyngitis showed no significant differences, informing antibiotic treatment choices.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Sore throat is a common ailment with various causes.
    • Bacterial pathogens, particularly Group A Streptococcus, are significant contributors to throat infections.
    • Accurate diagnosis and appropriate antibiotic selection are crucial for effective management.

    Purpose of the Study:

    • To determine the incidence of Group A haemolytic streptococci (Group A Strep) and other bacterial pathogens in patients with sore throats.
    • To compare pathogen isolation rates between patients with acute tonsillitis and acute pharyngitis versus a control group.
    • To correlate in-vitro antibiotic susceptibility data with prescribed treatments.

    Main Methods:

    • A controlled study involving throat swab collection from patients with sore throats and a control group.

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  • Bacteriological culture and identification of isolated pathogens.
  • In-vitro antibiotic susceptibility testing.
  • Comparison of isolation rates and antibiotic treatment regimens.

    • Main Results:

    • Group A Strep isolation was significantly higher in acute tonsillitis patients (38.8%) compared to controls (8.9%).
    • No significant difference in Group A Strep isolation rates was observed between acute pharyngitis patients and controls.
    • Isolation rates of other bacterial pathogens did not differ significantly between patient and control groups.
    • In-vitro antibiotic study results were compared with clinical treatment decisions.

    Conclusions:

    • Group A Strep is a key pathogen in acute tonsillitis, justifying targeted diagnostic and treatment approaches.
    • The role of other bacterial pathogens in sore throat etiology appears limited in this study population.
    • Correlation of in-vitro antibiotic data with clinical outcomes can guide optimal therapeutic strategies for streptococcal pharyngitis.