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Nefazadone-induced acute dystonic reaction
A Burda1, K Webster, J B Leikin
1Illinois Poison Center, Chicago, USA.
Veterinary and Human Toxicology
|October 6, 1999
Summary
Nefazodone, a medication, can cause acute dystonic reactions, characterized by involuntary movements like lip smacking. Prompt treatment with diphenhydramine and benztropine resolved the patient's symptoms.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Medicine
Background:
- Nefazodone is an antidepressant medication.
- Acute dystonic reactions are involuntary muscle contractions.
Observation:
- A 53-year-old patient experienced lip smacking and gesturing 2 hours after a first dose of nefazodone.
- The patient had previously taken meclizine without adverse effects.
Findings:
- Nefazodone was identified as the likely cause of the acute dystonic reaction.
- Diphenhydramine and benztropine effectively resolved the patient's symptoms within one hour.
Implications:
- Nefazodone should be recognized as a potential cause of acute dystonic reactions.
- This case highlights the importance of considering medication side effects in diagnosing movement disorders.