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A retrospective look at horses exhibiting unusual clinical signs after exercising on L-NAME
1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.
Veterinary and Human Toxicology
|October 6, 1999
Abstract:
Three of 5 horses exercising on L-NAME (NG-nitro-L-arginine methyl ester) exhibited unusual clinical signs towards the end of exercise bouts and post-exercise. L-NAME is a nitric oxide synthase inhibitor which blocks synthesis of nitric oxide from L-arginine. The induced absence of nitric oxide may have lead to the clinical signs observed.