Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lactose malabsorption diagnosis with H2 breath test].

A Sevá-Pereira1, R de C da Silva, R A Pereira-Filho

  • 1Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas-UNICAMP. adriseva@turing.unicamp.br

Arquivos De Gastroenterologia
|October 8, 1999
PubMed
Summary

The area under the curve of expired hydrogen (ASC-H2) after a lactose overload test reliably diagnoses lactose malabsorption. Measuring the maximum increase in expired hydrogen (delta-H2) is not a reliable diagnostic method.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of severe autoimmune thrombocytopenic purpura and Crohn's disease.

The American journal of gastroenterology·1997
Same author

Diagnostic value of fecal leukocytes in chronic bowel diseases.

Sao Paulo medical journal = Revista paulista de medicina·1994
Same author

[Use of fiber enriched biscuit in the treatment of chronic intestinal constipation].

Revista paulista de medicina·1991
Same author

[The pattern of bone marrow lesions in acquired immunodeficiency (AIDS)].

Revista do Instituto de Medicina Tropical de Sao Paulo·1988
Same author

[Absorption of medium chain triglycerides in patients with blind loop syndrome].

Arquivos de gastroenterologia·1988
Same author

[Qualitative microscopic evaluation of fecal fats. Comparative study].

Arquivos de gastroenterologia·1986

Area of Science:

  • Gastroenterology
  • Clinical Diagnostics
  • Biochemistry

Context:

  • Lactose malabsorption is a common condition affecting gastrointestinal health.
  • Accurate diagnostic methods are crucial for effective patient management.
  • Breath hydrogen testing is a widely used, non-invasive diagnostic tool.

Purpose:

  • To evaluate the diagnostic reliability of different metrics derived from breath hydrogen testing for lactose malabsorption.
  • To compare the accuracy of the maximum increase in expired hydrogen (delta-H2) versus the area under the curve (ASC-H2) in diagnosing lactose malabsorption.

Summary:

  • This study assessed 105 subjects undergoing a lactose overload test, measuring expired hydrogen and blood glucose.
  • Results indicate that the area under the curve of expired hydrogen (ASC-H2) significantly correlates with blood glucose changes, unlike the maximum increase (delta-H2).

Related Experiment Videos

  • Optimal cutoff values for ASC-H2 were determined using linear regression, ROC curves, and Q-Q plots, demonstrating high sensitivity, specificity, and accuracy.

    • Impact:

    • The findings suggest that ASC-H2 calculation is a reliable method for diagnosing lactose malabsorption in clinical practice.
    • This study provides validated cutoff values for ASC-H2, enhancing the diagnostic precision of breath hydrogen testing.
    • The research highlights the limitations of using delta-H2 for diagnosing lactose malabsorption, guiding clinicians towards more accurate diagnostic approaches.