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[Isoniazid acetylation in Gilbert's syndrome]
Arquivos De Gastroenterologia
|October 1, 1985
Summary
Gilbert's syndrome does not affect isoniazid acetylation capacity. This study found similar slow acetylator proportions in patients with Gilbert's syndrome compared to controls, indicating no interference in liver function.
Area of Science:
- Pharmacogenetics
- Hepatology
- Drug Metabolism
Context:
- Gilbert's syndrome is a common genetic liver condition.
- Isoniazid acetylation is a key metabolic pathway.
- Assessing drug metabolism in patients with liver conditions is crucial.
Purpose:
- To investigate the impact of Gilbert's syndrome on isoniazid acetylation.
- To determine if hepatic acetylation capacity is altered in individuals with Gilbert's syndrome.
Summary:
- Phenotyped isoniazid acetylators in 19 Caucasoid patients with Gilbert's syndrome.
- Measured acetylisoniazid in urine to assess acetylation.
- Found similar proportions of slow acetylators in patients and controls.
Impact:
- Gilbert's syndrome does not appear to interfere with isoniazid acetylation.
- This finding is relevant for pharmacogenetic studies and clinical practice involving isoniazid.
- Suggests preserved hepatic drug-metabolizing enzyme function in Gilbert's syndrome.