Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracerebral calcification in systemic sclerosis.

E Heron1, A Hernigou, G Chatellier

  • 1Service de Médecine Vasculaire and Centre Claude Bernard de Recherche sur les Maladies Vasculaires Périphériques, Paris Cedex, France. emmanuel.heron@brs.ap-hop-paris.fr

Stroke
|October 8, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BACT-URIE: A Novel Score Integrating Bacteriuria to Predict Infective Endocarditis in Patients With <i>Staphylococcus aureus</i> Bacteremia.

Open forum infectious diseases·2026
Same author

Orbital soft-tissue perineurioma.

Journal francais d'ophtalmologie·2025
Same author

Amputation-free survival in the long-term follow-up and gender-related characteristics in patients revascularized for critical limb ischemia.

Journal de medecine vasculaire·2023
Same author

Ocular motor nerve palsy in patients with diabetes: High-resolution MR imaging of nerve enhancement.

Journal francais d'ophtalmologie·2023
Same author

Peri-procedural complications following endovascular revascularization for critical limb ischemia.

Journal de medecine vasculaire·2022
Same author

Factors associated with psychological symptoms in hospital workers of a French hospital during the COVID-19 pandemic: Lessons from the first wave.

PloS one·2022

Systemic sclerosis patients show higher rates of intracerebral calcification compared to controls. This finding suggests a direct link between systemic sclerosis and cerebrovascular changes, potentially linked to Raynaud

Area of Science:

  • Neurology
  • Rheumatology
  • Radiology

Background:

  • Systemic sclerosis is a connective tissue disease characterized by fibrosis, vascular abnormalities, and autoimmune dysfunction.
  • Previous autopsy studies noted advanced cerebrovascular calcification in systemic sclerosis patients.
  • The precise prevalence and implications of intracerebral calcification in systemic sclerosis remain under-investigated.

Purpose of the Study:

  • To prospectively evaluate the occurrence of intracerebral calcification in patients diagnosed with systemic sclerosis.
  • To compare the prevalence of brain calcification in systemic sclerosis patients with age- and sex-matched controls.

Main Methods:

  • A prospective, unenhanced computed tomography (CT) brain scan study was performed on 37 consecutive systemic sclerosis patients.

Related Experiment Videos

  • Images were independently reviewed by blinded interpreters.
  • Each patient was compared with two age- and sex-matched control subjects.

    • Main Results:

    • Intracerebral calcification was detected in 32.4% of systemic sclerosis patients versus 9.5% of controls (P=0.006).
    • Calcification prevalence in patients correlated significantly with the duration of Raynaud's phenomenon (P=0.005).
    • No significant association was found between intracerebral calcification and patient age (P=0.086).

    Conclusions:

    • Intracerebral calcification is significantly more prevalent in patients with systemic sclerosis.
    • These findings support a strong association between systemic sclerosis and primary cerebrovascular changes.
    • The study suggests that systemic sclerosis may directly contribute to the development of calcification within cerebral vasculature.