BACT-URIE: A Novel Score Integrating Bacteriuria to Predict Infective Endocarditis in Patients With Staphylococcus...

Infective endocarditis (IE) is a serious complication of Staphylococcus aureus bacteremia (SAB). Systematic echocardiographic evaluation, especially when including transesophageal echocardiography, is resource-intensive. Existing risk scores do not include S. aureus bacteriuria, a potential marker of hematogenous spread. We assessed whether bacteriuria improves IE risk stratification.

We retrospectively analyzed 2 temporally distinct cohorts of adult SAB patients in a French tertiary hospital: a derivation cohort (2012-2019, n = 233) and a validation cohort (2020-2023, n = 156). Patients with proven urinary tract infection were excluded. Logistic regression identified predictors of IE, which were converted into weighted points to develop 2 scores: day 1 (baseline variables) and day 4 (including persistent bacteremia ≥72 hours). Performance was compared with VIRSTA and PREDICT.

Infective endocarditis occurred in 14.6% of the derivation cohort and 14.7% of the validation cohort. Independent predictors were intracardiac devices, community acquisition, bacteriuria, septic emboli, and persistent bacteremia. AUROCs for the day 1 and day 4 scores were 0.78 and 0.81 in derivation, and 0.91 and 0.93 in validation. At thresholds of >2 and >3, sensitivities were 67.65% and 70.59%, with negative predictive values of 93.29% and 93.83%, respectively. Compared with VIRSTA and PREDICT, BACT-URIE showed higher sensitivity in this cohort.

BACT-URIE is an exploratory score incorporating S. aureus bacteriuria to predict IE in SAB. Prospective multicenter validation is required before clinical implementation.