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[The antimutagenic activity of aspartame]
A V Kulakova1, E G Belogolovskaia, A V Oreshchenko
1Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|October 8, 1999
Abstract:
The method of chromosome aberration count in the bone marrow cells of C57B1/6 mice was used to study the influence of aspartame on the cytogenetic effects of dioxydin and cyclophosphan. Aspartame (0.4-40 mg/kg) was found to possess antimutagenic properties in relation to the listed mutagens. The discovered antimutagenic activity of aspartame was manifested more when it was injected for 5 days before the administration of a mutagen, whereas in joint administration of aspartame with the mutagens, the substitute for sugar did not change the clastogenic effect of dioxydin and cyclophosphan.