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Atopy parameters in asthmatic infants.

A Tridon1, J L Fauquert, P Dibet

  • 1Immunology Laboratory, Faculty of Pharmacy, Clermont-Ferrand, France.

Journal of Investigational Allergology & Clinical Immunology
|October 8, 1999
PubMed
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This study found that young asthmatic infants show diverse atopy markers, with specific IgE often positive when skin tests are not. The cellular allergen stimulation test (CAST) indicated reactivity, not just sensitization, in infants with other positive atopy signs.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine

Background:

  • Atopy is a significant risk factor for asthma development in infants.
  • Early identification of atopy phenotypes is crucial for understanding disease heterogeneity.

Purpose of the Study:

  • To evaluate various atopy parameters in asthmatic infants aged 1-3 years.
  • To investigate the relationship between nonspecific and specific atopy markers, including cellular allergen stimulation test (CAST).

Main Methods:

  • Assessed 44 asthmatic infants using total IgE, eosinophilia, specific IgE, skin tests, and polyvalent CAST against 21 allergens.
  • Compared results of different atopy assessment methods.

Main Results:

  • 27 out of 44 infants met at least one atopy criterion.

Related Experiment Videos

  • Specific IgE tests were more frequently positive than skin tests, with frequent dissociations between the two.
  • Polyvalent CAST was positive only when other atopy criteria were also met, suggesting reactivity.

    • Conclusions:

    • Asthmatic infants exhibit heterogeneous atopy expression with distinct phenotypes.
    • Specific IgE and skin tests show significant discordance in this population.
    • CAST results in infants suggest underlying reactivity rather than solely sensitization.