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Altered seizure susceptibility after high-frequency transcranial magnetic stimulation in rats
1Institute of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany. uebert@pharma.tiho-hannover.de
Abstract:
The long-term effect of repetitive transcranial magnetic stimulation (rTMS) on the susceptibility of amygdala kindling was studied. Two weeks after a single high-frequency rTMS train (120 A/micros, 20 Hz for 3 s), the rats had a 55% higher threshold for induction of epileptic afterdischarges compared with sham-treated or control rats. However, subsequent kindling revealed no difference between rTMS-treated and control rats. Our data suggest that a single rTMS train has long-term effects on the neuronal excitability. These effects may be anticonvulsant and therefore support the safety of rTMS in clinical use.