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Sacral nerve stimulation and diurnal urine volume
M Ishigooka1, D H Zermann, R Doggweiler
1Neurourology Unit, Division of Urology, University of Colorado Health Sciences Center, Denver, Colo., USA.
European Urology
|October 12, 1999
Summary
Sacral nerve stimulation (SNS) not only improves bladder control but also increases urine production. This study found a significant rise in daily urine output and voided volume following SNS, suggesting a direct effect on the body's fluid regulation.
Area of Science:
- Urology
- Neuroscience
- Endocrinology
Background:
- Sacral nerve stimulation (SNS) is a treatment for bladder dysfunction.
- Discrepancies in urine output during screening raised questions about SNS's effect on urine production.
Purpose of the Study:
- To investigate the potential direct modulatory influence of SNS on urine production.
- To evaluate the relationship between urine output and neuromodulation.
Main Methods:
- Analysis of voiding diaries from 40 patients undergoing SNS.
- Diaries were collected at baseline, during peripheral nerve evaluation (PNE), and after permanent implantation.
Main Results:
- A significant increase in average volume per void was observed in 39 patients during PNE.
- Twenty-four-hour urine volume was statistically greater during PNE compared to baseline.
- Volume per void and diurnal urine volume remained significantly higher after permanent SNS implantation.
Conclusions:
- SNS influences both bladder function and urine production.
- Increased voided volume correlates with increased 24-hour urine output.
- The mechanism may involve altered antidiuretic hormone release, indicating hypothalamic involvement in micturition.