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[Effects of an oxacephem antibiotic on liver function in orthopedic surgery]
M Kuroyama1, K Otori, S Yokota
1Department of Pharmacy, Kitasato University East Hospital, Kanagawa, Japan.
Abstract:
The subjects were 531 patients who underwent orthopedic surgery. Flomoxef was administered, and liver function was examined before and after administration. Abnormal liver function after administration of flomoxef was found in 14.3% of patients. In male patients, a high rate of 18.8% was observed. A particularly high rate of 37.0% was obtained among patients who showed GOT values of more than 40 U/L before treatment with flomoxef. The prevalence of abnormal GOT and GPT values after administration of flomoxef was 3.6% and 13.2%, respectively. These values were significantly higher than those obtained with other cephem antibiotics. These rates of occurrence of abnormally high GOT and GPT are obviously higher than those submitted at the time of approval and reported in the drug use investigation. The prevalence of abnormal liver function values was high in patients receiving flomoxef, and particularly high in male patients and patients whose GOT was high before administration of flomoxef. Therefore, sufficient check of liver function appears important when administration of flomoxef to these types of patients is intended.
Insights
Flomoxef administration in orthopedic surgery patients led to abnormal liver function in 14.3%, especially in males and those with pre-existing high GOT levels. Liver function monitoring is crucial for these patients.
Area of Science:
- Pharmacology
- Hepatology
- Clinical Medicine
Background:
- Flomoxef is an antibiotic used in orthopedic surgery.
- Liver function abnormalities are a potential adverse effect of antibiotic therapy.
Purpose of the Study:
- To investigate the incidence and characteristics of liver function abnormalities following flomoxef administration in orthopedic surgery patients.
- To compare the rates of abnormal liver function with other cephem antibiotics.
Main Methods:
- Prospective study involving 531 orthopedic surgery patients.
- Administration of flomoxef.
- Assessment of liver function (GOT, GPT) before and after flomoxef administration.
Main Results:
- 14.3% of patients exhibited abnormal liver function post-flomoxef.
- Higher rates observed in males (18.8%) and patients with pre-treatment GOT > 40 U/L (37.0%).
- Abnormal GOT and GPT rates (3.6%, 13.2%) were significantly higher than with other cephem antibiotics and previously reported data.
Conclusions:
- Flomoxef is associated with a notable prevalence of abnormal liver function, particularly in specific patient subgroups.
- Enhanced liver function monitoring is recommended for male patients and those with elevated baseline GOT levels receiving flomoxef.
- The observed rates suggest a potentially higher risk profile for flomoxef-induced hepatotoxicity compared to other cephems.
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