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Thiazolidinediones with thyroid hormone receptor agonistic activity
M Ebisawa1, N Inoue, H Fukasawa
1Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|October 12, 1999
Abstract:
Several thiazolidinedione derivatives (3-7) were designed and synthesized as candidate thyromimetic drugs. Among them, the dihydrogenated compounds, such as 5-2-[[4-(3-tert-butyl-4-hydroxyphenyl)oxy-3,5-diiodophenyl] ethyl]-2,4-thiazolidinedione (6b) and its 3-isopropyl analog (7b), exhibited potent thyroid hormone receptor alpha 1 (TR alpha 1) activation activity.