Related Experiment Videos
Measuring water distribution in extrudates using magnetic resonance imaging (MRI)
G Tomer1, M D Mantle, L F Gladden
1Department of Pharmaceutics, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK.
International Journal of Pharmaceutics
|October 16, 1999
Summary
Magnetic resonance imaging (MRI) revealed uniform water distribution in extruded pastes. Faster extrusion speeds resulted in greater water structure, indicated by a lower percolation threshold.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Understanding water distribution in pharmaceutical extrudates is crucial for drug delivery.
- Microcrystalline cellulose (MCC) is a common excipient in extrudates.
Purpose of the Study:
- To investigate water distribution in extrudates using magnetic resonance imaging (MRI).
- To correlate water structure with extrusion parameters and extrusion force.
Main Methods:
- Extrusion of model drug pastes with MCC and varying water content using a ram extruder.
- Analysis of water distribution in extrudates via MRI.
- Calculation of percolation threshold to assess water structure.
Main Results:
- Water distribution within the extrudates was found to be remarkably uniform.
- Extrudates produced at faster extrusion speeds exhibited a significantly lower percolation threshold, suggesting enhanced water structuring.
- A significant correlation was observed between the percolation threshold and extrusion force.
Conclusions:
- MRI is effective for evaluating water distribution in extrudates.
- Extrusion speed influences water structure in pharmaceutical extrudates.
- Percolation threshold serves as a valuable indicator of water structure and relates to extrusion forces.