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[Thyroid function in elderly with neoplasms]
U Tellini1, L Pellizzari, B Pravadelli
1Dipartimento di Gerontologia e Geriatria, Azienda Ospedaliera, Verona.
Minerva Medica
|October 16, 1999
Summary
Sick euthyroid syndrome (ESS) affects 58% of elderly cancer patients, particularly those with weight loss. This study highlights the high incidence of ESS type 1 in this vulnerable population.
Area of Science:
- Endocrinology
- Oncology
- Geriatrics
Context:
- Severe illnesses can alter thyroid hormone metabolism, leading to sick euthyroid syndrome (ESS).
- ESS is characterized by changes in thyroid hormone levels, potentially influenced by inflammatory mediators.
- The prognostic significance of thyroid dysfunction in severe illness remains debated.
Purpose:
- To investigate the incidence and characteristics of ESS in elderly patients hospitalized with cancer.
- To identify clinical and laboratory factors associated with ESS in this population.
Summary:
- This study found a 58% incidence of ESS in 220 elderly cancer patients.
- ESS type 1 (low FT3, normal FT4, normal TSH) was the most common form.
- Higher ESS incidence correlated with significant weight loss (86%) and poor clinical condition, with observed correlations between FT3 and cholesterol, proteins, sodium, and FT4.
Impact:
- The findings underscore the high prevalence of ESS in elderly cancer patients, especially those experiencing significant weight loss.
- Results highlight the need for further research into the management of ESS in this demographic.
- The study identifies specific laboratory parameters associated with ESS, potentially aiding in risk stratification.