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A nucleotide deletion in exon 4 is responsible for an HLA-A null allele (A*0105N)
F Poli1, P Bianchi, M Scalamogna
1Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico IRCCS, Milan, Italy. nitpmi@polic.cilea.it
Tissue Antigens
|October 16, 1999
Abstract:
We report herein the identification of a new HLA-A null allele. This allele, A*0105N, was detected during histocompatibility testing of a cord blood donor and the respective mother. Serologic typing results contrasted those obtained with DNA typing that alone showed the presence of HLA-A*01. ThisA*0105N was due to a nucleotide deletion in exon 4 that altered the reading frame, causing a premature termination.