Related Experiment Video
Updated: Oct 18, 2026
12:26
An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation
Published on: June 2, 2018
Degree of neuronal activation following FG-7142 changes across regions during development
P J Lyss1, S L Andersen, C J LeBlanc
1McLean Hospital, 115 Mill Street, Belmont, MA 02178, USA.
Brain Research. Developmental Brain Research
|October 16, 1999
Abstract:
We report that FG-7142 (20 mg/kg) differentially increased c-fos in the prefrontal cortex, nucleus accumbens, and striatum of rats 10, 18, 45, and 100 days of age. FG-7142 selectively activated the cortex in adults (70.7+/-3.0%), but the pattern was stronger in nucleus accumbens (83.4+/-9.8%) in younger subjects. These results are consistent with the delayed maturation of the cortex, and show that stress produces more diffuse effects early in life.
