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Degree of neuronal activation following FG-7142 changes across regions during development
P J Lyss1, S L Andersen, C J LeBlanc
1McLean Hospital, 115 Mill Street, Belmont, MA 02178, USA.
Brain Research. Developmental Brain Research
|October 16, 1999
Abstract:
We report that FG-7142 (20 mg/kg) differentially increased c-fos in the prefrontal cortex, nucleus accumbens, and striatum of rats 10, 18, 45, and 100 days of age. FG-7142 selectively activated the cortex in adults (70.7+/-3.0%), but the pattern was stronger in nucleus accumbens (83.4+/-9.8%) in younger subjects. These results are consistent with the delayed maturation of the cortex, and show that stress produces more diffuse effects early in life.