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Fish oil reduces gastric acid secretion
C Riber1, M Wøjdemann, T Bisgaard
1Dept of Surgical Gastroenterology C, Rigshospitalet, University of Copenhagen, Denmark.
Scandinavian Journal of Gastroenterology
|October 16, 1999
Summary
Fish oil infused into the small intestine significantly reduced gastrin-stimulated gastric acid secretion in healthy humans. Trioleate, however, did not affect acid secretion, indicating a specific effect of fish oil.
Area of Science:
- Gastroenterology
- Human Physiology
- Nutritional Science
Background:
- Gastric acid secretion is regulated by hormones like gastrin, cholecystokinin (CCK), and secretin.
- Dietary fats can influence gastrointestinal hormone release and gastric function.
Purpose of the Study:
- To investigate the effects of intraduodenal fish oil versus trioleate on gastric acid secretion.
- To examine the impact of these substances on the release of gastrin, CCK, and secretin.
Main Methods:
- Healthy volunteers underwent intraduodenal perfusion with fish oil or trioleate.
- Gastric acid secretion was measured during background gastrin-17 stimulation.
- Plasma levels of gastrin, CCK, and secretin were monitored.
Main Results:
- Fish oil significantly reduced gastrin-stimulated gastric acid secretion.
- Fish oil perfusion led to a significant increase in plasma CCK levels.
- Trioleate did not affect gastric acid secretion but tended to increase CCK and decrease secretin.
Conclusions:
- Intraduodenal fish oil administration inhibits gastrin-stimulated gastric acid secretion in humans.
- The observed effect of fish oil may involve modulation of CCK release.