Related Experiment Videos
Design and synthesis of novel dihydropyridine alpha-1a antagonists
M R Marzabadi1, X Hong, D Nagarathnam
1Department of Chemistry, Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA.
Bioorganic & Medicinal Chemistry Letters
|October 16, 1999
Abstract:
A series of analogs of SNAP 5150 containing heteroatoms at C2 or C6 positions is described. Herein, we report that the presence of alkyl substituted heteroatoms at the C2(6)-positions of the dihydropyridine are well tolerated. In addition, 15 inhibited the phenylephrine induced contraction of dog prostate tissue with a Kb of 1.5 nM and showed a Kb (DBP, dogs, microg/kg)/Kb (IUP, dogs, microg/kg) ratio of 14.8/2.5.