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Laryngeal contact granuloma.
1Department of Otolaryngology, University of Tennessee, Memphis, School of Medicine, 38163, USA.
The Laryngoscope
|October 16, 1999
Summary
Proton-pump inhibitor (PPI) medication effectively treats laryngeal contact granulomas, with most patients showing complete resolution or significant regression. This treatment is beneficial even without clear gastroesophageal reflux symptoms.
Area of Science:
- Otolaryngology
- Gastroenterology
Background:
- Laryngeal contact granulomas are benign growths often associated with voice misuse and gastroesophageal reflux.
- Treatment options for laryngeal contact granulomas can be challenging, with varying success rates.
Purpose of the Study:
- To evaluate the efficacy of proton-pump inhibitor (PPI) medication in treating laryngeal contact granulomas.
- To assess outcomes in patients with laryngeal contact granulomas, irrespective of reflux symptoms.
Main Methods:
- A prospective study involving 21 patients diagnosed with laryngeal contact granulomas.
- Treatment primarily involved proton-pump inhibitor (PPI) medication, with follow-up via endoscopy and patient interviews.
- Alternative treatments included H2 blockers, surgical excision, and botulinum toxin injections for non-responders or those intolerant to PPIs.
Main Results:
- 14 out of 18 patients on PPI medication achieved complete resolution of their laryngeal contact granulomas.
- An additional 4 patients on PPIs experienced significant lesion regression.
- One patient required surgical excision, and two resolved after botulinum toxin injection; only one of three patients on H2 blockers saw resolution.
Conclusions:
- Proton-pump inhibitor (PPI) medication demonstrates significant effectiveness in treating laryngeal contact granulomas.
- PPI therapy is a viable treatment option for laryngeal contact granulomas, even when gastroesophageal reflux symptoms are not apparent.