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Glomerular formation in the developing rat olfactory bulb.

H B Treloar1, A L Purcell, C A Greer

  • 1Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520-8082, USA.

The Journal of Comparative Neurology
|October 19, 1999
PubMed
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Olfactory receptor cell axons initiate glomeruli formation by entering the olfactory bulb's dendritic zone. Subsequent coalescence of dendritic and glial processes forms these structures, revealing a timeline of cellular interactions during development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Olfactory glomeruli are key structures in the olfactory bulb responsible for initial signal processing.
  • Understanding the precise cellular interactions during glomerular formation is crucial for comprehending olfactory system development.

Purpose of the Study:

  • To elucidate the spatiotemporal cellular interactions during the formation of olfactory glomeruli in the developing rat olfactory bulb.
  • To establish a detailed timeline of cell type interactions during late embryonic development.

Main Methods:

  • Confocal microscopy was utilized to visualize cellular components.
  • Immunocytochemistry with specific markers for olfactory receptor cell axons, mitral/tufted cell dendrites, glial cells, and synapse-associated proteins was performed.

Related Experiment Videos

  • Double- and triple-labeling techniques were employed to analyze cellular co-localization.

    • Main Results:

    • Olfactory receptor cell axons penetrated the mitral/tufted cell dendritic zone between embryonic days 17 and 18.
    • Protoglomeruli formed at embryonic day 19, with adult glomerular structure emerging by birth.
    • Mitral/tufted cell dendrites and astrocytes associated with protoglomeruli starting at embryonic day 21.
    • Synaptic constituents (synaptophysin) were expressed as early as embryonic day 17, preceding mature axon appearance.

    Conclusions:

    • Olfactory receptor cell axon penetration into the dendritic zone is the initiating event in glomeruli formation.
    • The subsequent integration of dendritic and glial processes into glomerular structures is secondary to axon arrival.
    • A precise temporal and spatial map of cellular interactions during olfactory bulb development was established.