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Cerebral hemorrhage and apoE.
C Garcia1, T Pinho e Melo, L Rocha
1Instituto de Neurologia, Hospital de Santa Maria, P-1600 Lisbon, Portugal.
Journal of Neurology
|October 20, 1999
Summary
The apolipoprotein E (apoE) epsilon4 allele, linked to Alzheimer's disease, was not found to be significantly more common in patients with cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH) compared to other groups.
Area of Science:
- Neurology
- Genetics
- Pathology
Background:
- The epsilon4 allele of apolipoprotein E (apoE) is more prevalent in Alzheimer's disease (AD) patients.
- ApoE is linked to brain amyloid and cerebral amyloid angiopathy (CAA), a cause of lobar intracerebral hemorrhage (ICH).
Purpose of the Study:
- To investigate if the apoE epsilon4 allele frequency is higher in patients with CAA-related ICH compared to hypertensive ICH and normal populations.
- To examine the association between apoE polymorphism and lobar CAA-related ICH.
Main Methods:
- Compared apoE allele frequencies in four groups: lobar ICH patients, matched hypertensive ICH patients, matched normal controls, and population controls.
- Genotyping of apolipoprotein E alleles was performed for all participants.
Main Results:
- A trend towards higher apoE epsilon4 frequency was observed in lobar ICH patients, but this difference was not statistically significant across the groups.
- No significant difference in apoE allele frequencies was found between lobar ICH, hypertensive ICH, and control populations.
- Previous findings of increased apoE epsilon2 frequency in lobar ICH patients were not confirmed.
Conclusions:
- The relationship between apoE polymorphism and lobar CAA-related ICH requires further investigation.
- Current data do not strongly support a significant association between apoE epsilon4 and CAA-related ICH.