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Updated: Oct 18, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
[National study of the spread of hepatitis B to provide a foundation for future vaccination policy]
1Rijksinstituut voor Volksgezondheid en Milieu, Centrum voor Infectieziekten Epidemiologie, Bilthoven.
Abstract:
On May 1st, 1999, a study was started regarding the spread of hepatitis B in the Netherlands (the so-called BRON study). For one year, data will be collected on new cases of hepatitis B with respect to transmission route, source of infection and risk factors. In addition, by use of mailed questionnaires, information on risk factors will be collected within a large group of control subjects throughout the country. The BRON study is being carried out by the National Institute for Public Health and the Environment (RIVM) in co-operation with the municipal health services and medical laboratories. The results of this study should underpin future governmental policy decisions regarding universal or selective vaccination against hepatitis B.
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