Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multifunctional roles of thrombin.

S Narayanan1

  • 1Department of Pathology, New York Medical College, Metropolitan Hospital Center, NY 10029, USA.

Annals of Clinical and Laboratory Science
|October 21, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure of Complex Liquid-Liquid Extraction Organic Phases for Rare Earth Separations.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Effects of emotional spillover and exposure to interparental psychological aggression on momentary physiological linkage during naturalistic couple conflicts.

Biological psychology·2026
Same author

Motor imagery and self-recognition from actions.

NeuroImage·2025
Same author

Extracted Water Induces Concentration Fluctuations in Model Ternary Liquid-Liquid Extraction System.

The journal of physical chemistry. B·2025
Same author

Excipient Lung Disease and Fatal Outcome Among Young Adults: A Case Series on the Hidden Dangers of Intravenous Drug Abuse in India.

Annals of African medicine·2025
Same author

Initiation of H1-T6SS dueling between <i>Pseudomonas aeruginosa</i>.

mBio·2024

Thrombin is a key molecule in blood clotting, acting as both a procoagulant and anticoagulant. Its diverse roles include platelet activation, fibrin clot formation, and regulation of fibrinolysis, impacting inflammation and cell growth.

Area of Science:

  • Biochemistry
  • Hematology
  • Molecular Biology

Background:

  • Thrombin is a serine protease with critical roles in hemostasis.
  • It exhibits dual functions, acting as both a procoagulant and an anticoagulant.
  • Thrombin's activity is essential for physiological processes but requires tight regulation.

Purpose of the Study:

  • To elucidate the multifaceted roles of thrombin in coagulation and beyond.
  • To understand thrombin's mechanisms in both promoting and inhibiting clot formation.
  • To highlight thrombin's involvement in cellular processes and its regulation.

Main Methods:

  • Review of existing literature on thrombin's biochemical functions.
  • Analysis of thrombin's interactions with its receptors and substrates.

Related Experiment Videos

  • Examination of thrombin's signaling pathways in coagulation and cellular responses.

    • Main Results:

    • Thrombin promotes clot formation by activating platelets and coagulation factors (V, VIII, XI) and cross-linking fibrin.
    • It inhibits clot breakdown (fibrinolysis) by activating factor XI.
    • Thrombin acts as an anticoagulant via thrombomodulin, initiating fibrinolysis.
    • Thrombin exhibits chemotactic and mitogenic properties, influencing inflammation and cell growth.
    • Its role in brain development is also noted.

    Conclusions:

    • Thrombin is a pivotal, multifunctional molecule in hemostasis and beyond.
    • Its procoagulant and anticoagulant activities are precisely regulated.
    • Thrombin's broader biological functions include roles in inflammation, cell proliferation, and development.