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[Pigmented pemphigoid].

J F Poulain1, E Carmi, F Thelu

  • 1Service de Dermatologie et Vénéréologie, CHRU, Amiens.

Annales De Dermatologie Et De Venereologie
|October 26, 1999
PubMed
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This case report details a rare pigmented bullous pemphigoid presentation. The patient

Area of Science:

  • Dermatology
  • Immunodermatology
  • Autoimmune Blistering Diseases

Background:

  • Pigmented bullous pemphigoid (BP) presents with diverse clinical manifestations.
  • Bullous pemphigoid is a chronic autoimmune blistering disease affecting the skin.

Observation:

  • A 70-year-old woman with a history of breast adenocarcinoma developed pigmented macules and subsequently, disseminated tight bullae.
  • The patient had phototype IV skin, potentially explaining the pigmented lesions.

Findings:

  • Histopathology revealed infraepidermic bullae.
  • Direct immunofluorescence showed linear C3 deposits along the basal membrane zone.
  • Immunoblotting confirmed the presence of the 180 kDa minor bullous pemphigoid antigen.

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Implications:

  • This atypical presentation highlights the varied clinical spectrum of bullous pemphigoid.
  • Accurate diagnosis relies on integrating clinical, histological, and immunopathological findings.
  • The pigmented variant may be associated with specific patient characteristics, such as skin phototype.