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Synthesis and antitumor activity of goniofufurone analogues
H B Mereyala1, R R Gadikota, M Joe
1Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad. root@csiict.ren.nic.in
Bioorganic & Medicinal Chemistry
|October 26, 1999
Abstract:
Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43. Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly.