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Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A
G S Crowhurst1, A R Dalby, M N Isupov
1Schools of Chemistry, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, England.
Acta Crystallographica. Section D, Biological Crystallography
|October 26, 1999
Abstract:
The crystal structure of the tetrameric glycolytic enzyme phosphoglycerate mutase from the yeast Saccharomyces cerevisiae has been determined to 1.7 A resolution in complex with the sugar substrate. The difference map indicates that 3-phosphoglycerate is bound at the base of a 12 A cleft, positioning C2 of the substrate within 3.5 A of the primary catalytic residue, histidine 8.