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Lispro insulin: adsorption and stability in selected intravenous devices
The Diabetes Educator
|October 26, 1999
Summary
Lispro insulin adsorption and stability match human insulin. A prewash technique can reduce infusion lag time for accurate dosing.
Area of Science:
- Pharmacology
- Biochemistry
Background:
- Insulin analogs like lispro insulin are widely used for diabetes management.
- Understanding their adsorption and stability in infusion systems is crucial for effective therapy.
Purpose of the Study:
- To compare the adsorption characteristics and stability of lispro insulin with recombinant human regular insulin.
- To evaluate the impact of various factors on insulin release profiles from intravenous infusion systems.
Main Methods:
- Evaluated lispro insulin and human regular insulin using intravenous infusion sets and syringes.
- Tested solutions of 0.9% NaCl or 5% dextrose.
- Determined effects of container type, infusion rate, concentration, filters, and storage on release profiles.
Main Results:
- Lispro insulin and m-cresol demonstrated chemical stability.
- Both insulins exhibited steady release rates after an initial lag time, which was longer with bag infusion than syringe infusion.
- Higher concentration, faster flow rate, and prewashing tubing reduced lag time.
Conclusions:
- Lispro insulin adsorption profiles are similar to human regular insulin in both syringes and bags.
- A 'load-and-sit' prewash can minimize lag time, enabling more precise patient dose calculations.