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Updated: Aug 13, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Vinylpyrrolidine-beta-cyclodextrin copolymer: a novel chiral selector for capillary electrophoresis
M Chiari1, V Desperati, M Cretich
1Institute of Biocatalysis and Molecular Recognition, CNR, Milano, Italy. chiari@ico.mi.cnr.it
Abstract:
The synthesis and characterization of a novel polymer consisting of an alkyl backbone and pendant beta-cyclodextrin units, obtained by radical copolymerization of vinylpyrrolidone and methacryloyl-beta-cyclodextrin (PVP-beta-CD), was reported. The ability of this copolymer to act as a capillary electrophoresis (CE) chiral selector was investigated in the separation of a mixture of basic drugs. The influence of polymeric cyclodextrin concentration, temperature, and pH on the separation of the test analytes was assessed and the advantage of using the polymeric selector over native beta-cyclodextrin was demonstrated.
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