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Corneal wound healing following laser in situ keratomileusis (LASIK): a histopathological study in rabbits
1Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
The British Journal of Ophthalmology
|October 27, 1999
Abstract
Aims:
To investigate the histopathological changes of rabbit corneas after laser in situ keratomileusis (LASIK) and to evaluate the corneal wound healing process.
Methods:
A LASIK was performed on white rabbit eyes. Postoperatively, rabbits were killed on days 1 and 7, and at 1, 3, and 9 months.
Results:
Periodic acid Schiff (PAS) positive material and disorganised collagen fibre were seen along the interface of the corneal flap even 9 months after operation.
Conclusions:
The wound healing process still continued at 9 months after LASIK indicating that a much longer time than expected was required for corneal wound healing following LASIK.