The effect of ionised magnesium on coagulation using thromboelastography

Area of Science:

• Biochemistry
• Hematology
• Pharmacology

Background:

• Magnesium is an essential mineral with known therapeutic applications.
• Laboratory studies have yielded conflicting results regarding magnesium's anticoagulant activity.
• The clinical significance of magnesium's effect on coagulation remains uncertain.

Purpose of the Study:

• To investigate the in vivo effect of a therapeutic dose of magnesium sulfate on blood coagulation parameters.
• To determine if intravenous magnesium sulfate administration impacts hemostasis in healthy individuals.

Main Methods:

• Ten healthy volunteers received a 4g intravenous infusion of magnesium sulfate.
• Thromboelastography and analysis of hematological indices were performed before and after the infusion.
• Coagulation variables were compared pre- and post-magnesium sulfate administration.

Main Results:

• No significant changes were observed in most measured coagulation variables.
• A significant increase in the alpha angle on the thromboelastograph was noted post-infusion.
• Hematological indices remained largely unchanged.

Conclusions:

• Intravenous administration of magnesium sulfate at a therapeutic dose did not produce clinically significant alterations in blood coagulation.
• The observed increase in the alpha angle was not deemed clinically relevant in the context of overall coagulation.
• Further research may be warranted, but current findings suggest magnesium sulfate is safe concerning hemostasis in healthy subjects.