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1,2-Hydride Shift in the Biosynthesis of Pinguisane-type Sesquiterpenes
H Tazaki1, T Iwasaki1, Y Kawakami2
1a Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine.
Bioscience, Biotechnology, and Biochemistry
|December 14, 1999
Abstract:
A (2)H-NMR analysis of 6α-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide produced by axenic culture of liverwort Aneura pinguis in the presence of [4-(2)H2]-labeled mevalonate clarified the presence of a 1,2-hydride shift and retention of deuterium at the C-4 position in the biosynthesis of pinguisane-type sesquiterpenes from FPP.