Related Experiment Video
Updated: Sep 2, 2026
08:50
Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
A macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression in KK-Ay
Hisako Takahashi1,2, Hiromu Morimoto2, Hirofumi Inoue2
1Department of Agricultural Chemistry, School of Agriculture, Meiji University, Kanagawa, Japan.
Bioscience, Biotechnology, and Biochemistry
|September 1, 2026
Abstract:
Macrophage-conditioned medium models are widely used in obesity research, but correspondence with obese animals has not been examined. We compared the effects of Kaempferia parviflora in this model and KK-Ay diabetic obese model mice. Anti-inflammatory effects and restoration of uncoupling protein-1 (UCP-1) expression were observed in both models, indicating that the macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression.