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Related Experiment Videos

Cellular responses to whitlockite.

L M Ryan1, H S Cheung, R Z LeGeros

  • 1Department of Medicine, Division of Rheumatology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, Wisconsin 53226, USA.

Calcified Tissue International
|December 14, 1999
PubMed
Summary
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Whitlockite crystals in cartilage may contribute to arthritis. While they stimulate cell proliferation and matrix metalloproteinase secretion, they are less potent than calcium phosphate crystals lacking magnesium.

Area of Science:

  • Biochemistry
  • Orthopedics
  • Crystal-induced pathology

Background:

  • Whitlockite crystals are found in articular cartilage.
  • Their role in cartilage degeneration is not fully understood.

Purpose of the Study:

  • To investigate the in vitro effects of whitlockite crystals on cartilage cells.
  • To assess their potential to induce cartilage degeneration.

Main Methods:

  • In vitro study of whitlockite crystal effects on chondrocytes.
  • Assay for cell proliferation, stromelysin, and collagenase synthesis and secretion.

Main Results:

  • Whitlockite crystals stimulated chondrocyte proliferation.
  • They also stimulated the synthesis and secretion of stromelysin and collagenase.

Related Experiment Videos

  • These effects were less pronounced than those of calcium phosphate crystals without magnesium.

    • Conclusions:

    • Whitlockite crystals elicit cellular responses suggesting potential pathogenicity in arthritis.
    • Their potency in inducing these responses is lower than that of non-magnesium-containing calcium phosphate crystals.