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Strategies for particle design using supercritical fluid technologies.

York1

  • 1Drug Delivery Group, The School of Pharmacy, University of Bradford, Bradford UK BD7 1DP.

Pharmaceutical Science & Technology Today
|November 5, 1999
PubMed
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Supercritical fluid technologies offer advanced methods for pharmaceutical particle engineering, overcoming limitations of traditional techniques for improved drug delivery systems. This review explores their potential and challenges.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Engineering
  • Chemical Engineering

Background:

  • Conventional methods for pharmaceutical particle formation face limitations in achieving desired characteristics for advanced drug delivery.
  • There is a growing need for precise control over particle size, polymorphic form, and other properties for targeted drug delivery.

Purpose of the Study:

  • To review recent progress in applying supercritical fluid technologies for pharmaceutical crystal and particle engineering.
  • To provide a perspective on the current status and future potential of supercritical fluid technology as a platform for drug delivery systems.

Main Methods:

  • Literature review of recent advancements in supercritical fluid technologies for pharmaceutical applications.
  • Analysis of studies focusing on particle size control, polymorphic engineering, and drug delivery system design using supercritical fluids.

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Main Results:

  • Supercritical fluid technologies demonstrate significant promise for engineering pharmaceutical particles with tailored characteristics.
  • These technologies enable precise control over particle size and polymorphic purity, crucial for specific drug delivery needs.

Conclusions:

  • Supercritical fluid technology is a viable and promising platform for advanced pharmaceutical particle engineering and drug delivery.
  • Future applications require addressing current challenges to fully realize the potential of this technology.