[Models for the study of memory and neurosteroids]
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Updated: Oct 18, 2026

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
Published on: August 20, 2020
C Mathis1, H Meziane, A Ungerer
1Laboratoire d'Ethologie et de Neurobiologie, URA 1295 CNRS, Université Louis Pasteur, Strasbourg, France. mathisc@currif.u-strasbg.fr
Abstract:
The steroids dehydroepiandrosterone sulfate (DHEA-S) and pregnenolone sulfate (Preg-S) are naturally synthetized in the brain. They improve short term and long term memory performances in a variety of learning tasks and models of amnesia in rodents. DHEA-S and Preg-S modulate GABAergic and glutamatergic synaptic transmission through direct interactions with GABA-A, NMDA and/or sigma 1 membrane receptors. In addition, these two neurosteroids facilitate the release of acetylcholine and modulate synaptic plasticity phenomena in cerebral structures, such as the hippocampus, known to play a role in learning and memory processes. The possible links between these actions and the promnestic effects of DHEA-S and Preg-S are discussed in the present review.
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