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[Use of multiple structural alignment for recognizing the type of protein spatial architecture]
Sh R Siuniaev1, F Aĭzenkhaber, V G Tumanian
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Biofizika
|November 2, 1999
Abstract:
A new approach to the inverse folding problem is proposed, which is based on the analysis of multiple structural alignments of protein families. The incorporation of multiple structure information allows one to take into account the variability of structural characteristics amongst protein structures of the same fold. The new method was tested on two highly populated structural families.