Painful lytic bone lesion in an adult with chronic myelogenous leukemia

The occurrence of blast cell granulocytic tumors (chloromas, myeloblastomas) associated with chronic myelogenous leukemia has been well documented. However, the production of lytic lesions by nonmyeloblastomatous hematopoietic cell forms in chronic myelogenous leukemia has been described only once previously. The pain associated with osteolysis in this particular patient preceded roentgenographic appearance of lytic lesion and diagnosis of chronic myelogenous leukemia. Biopsy of lytic lesion demonstrated infiltration with cell forms nearly identical with those of simultaneously performed bone marrow aspiration.