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Updated: Aug 11, 2026
10:25
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
Published on: March 19, 2016
Storage of blood components
1Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.
Current Opinion in Hematology
|November 5, 1999
Summary
Restrictive transfusion policies reduce surgical patient mortality. Improving red blood cell and platelet concentrate quality by removing leukocytes and monitoring bacterial contamination enhances patient safety.
Area of Science:
- Transfusion Medicine
- Hematology
- Surgical Patient Care
Background:
- Restrictive transfusion policies are linked to reduced mortality in surgical patients.
- Adverse effects of red blood cell transfusions may stem from contaminating leukocytes and poor cell function.
- Leukocyte removal from platelet concentrates (PCs) is crucial due to their immunogenicity and cytokine production during storage.
Purpose of the Study:
- To highlight the benefits of prestorage leukocyte removal in transfusion products.
- To discuss the significance of bacterial contamination in platelet concentrates.
- To emphasize methods for improving the quality and safety of transfusion products.
Main Methods:
- Review of recent studies on transfusion policies and outcomes.
- Analysis of the impact of leukocyte contamination on transfusion efficacy.
- Discussion of methods for leukocyte reduction in red blood cells and platelet concentrates.
- Evaluation of bacterial contamination in platelet concentrates and associated risks.
Main Results:
- Prestorage leukocyte removal offers significant advantages for transfusion products.
- While bacterial contamination of PCs is common, fatal complications are infrequent.
- Effective methods for routine bacterial culture of PCs exist and are implemented in some regions.
Conclusions:
- Improving the quality of red blood cells and platelet concentrates through leukocyte removal can mitigate transfusion-associated risks.
- Routine bacterial culturing of platelet concentrates is essential for patient safety.
- Optimizing transfusion practices, including product quality, is vital for surgical patient outcomes.
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