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Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children

J A Vanderhoof1, D B Whitney, D L Antonson

  • 1Department of Pediatrics, University of Nebraska, Omaha, USA.

The Journal of Pediatrics
|November 5, 1999
PubMed

Insights

Lactobacillus GG (LGG) effectively prevents antibiotic-associated diarrhea in children. This probiotic supplement significantly reduced diarrhea incidence and improved gut health during antibiotic treatment for common infections.

Area of Science:

  • Microbiology
  • Pediatric Gastroenterology
  • Clinical Therapeutics

Background:

  • Antibiotic-associated diarrhea (AAD) is a common side effect of antibiotic therapy in children.
  • Probiotics are being investigated as a potential strategy to mitigate AAD.
  • Lactobacillus casei sps. rhamnosus (Lactobacillus GG) is a well-studied probiotic strain.

Purpose of the Study:

  • To evaluate the efficacy of Lactobacillus GG (LGG) in preventing AAD in pediatric patients receiving oral antibiotics.
  • To assess the impact of LGG on stool frequency and consistency during antibiotic treatment.

Main Methods:

  • A double-blind, randomized, placebo-controlled trial was conducted.
  • 202 children (6 months–10 years) received either LGG (1x10^10 - 2x10^10 CFU/day) or placebo alongside oral antibiotics.
  • Investigators monitored gastrointestinal symptoms via caregiver interviews every 3 days.

Main Results:

  • Only 7 out of 188 children receiving LGG experienced diarrhea, compared to 25 in the placebo group.
  • LGG significantly reduced stool frequency and improved stool consistency by day 10 of antibiotic therapy.
  • The probiotic demonstrated a notable protective effect against AAD.

Conclusions:

  • Lactobacillus GG is an effective intervention for reducing the incidence of antibiotic-associated diarrhea in children.
  • LGG supplementation can be a valuable adjunct therapy for pediatric patients undergoing antibiotic treatment for common infections.
  • The findings support the use of Lactobacillus GG to manage antibiotic-induced gastrointestinal disturbances in children.
Abstract

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