[Platelet function during long term inhibition of labour by fenoterol/verapamil (author's transl)]

Platelet function has been studied in 22 patients (methods according to Born and Breddin) during tocolysis with long term administration of intravenous Fenoterol/Verapamil. The extend and speed of platelet aggregation, according to the Born test, were constant in the following 12 days except for a small increase on the second day. The phase of disaggregation remained unchanged. The reaction time to collagen was prolonged up to the 3rd-4th day. Spontaneous platelet aggregation showed a tendency to decrease up to day 3--4; thereafter, there was a return to the original values. The present data show that a hemostatic action in platelet function cannot be expected during long term tocolysis. Thus, there is no evidence that Fenoterol acts as an inhibitor of platelet aggregation in pregnancy.