Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Famciclovir update. Chronic hepatitis B.

C L Young1

  • 1SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426-0989, USA.

Advances in Experimental Medicine and Biology
|November 5, 1999
PubMed
Summary

Famciclovir shows promise as a safe and convenient oral treatment for chronic hepatitis B infection. Further phase III studies are anticipated to confirm these findings in a broader patient population.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The acoustical behavior of Acheta domesticus L. (Orthoptera: Gryllidae) following sublethal doses of parathion, Dieldrin and Sevin.

Oecologia·2017
Same author

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties.

Lab on a chip·2016
Same author

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system.

British journal of cancer·2014
Same author

Health resource utilization associated with switching to risperidone long-acting injection.

Acta psychiatrica Scandinavica·2006
Same author

The equine hypophysis: a gland for all seasons.

Reproduction, fertility, and development·2002
Same author

Famciclovir treatment of hepatitis B infection following liver transplantation: a long-term, multi-centre study.

Transplant infectious disease : an official journal of the Transplantation Society·2001

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Chronic hepatitis B infection poses a significant global health challenge.
  • Current treatment options for chronic hepatitis B have limitations.
  • Famciclovir is an antiviral medication with potential for hepatitis B treatment.

Purpose of the Study:

  • To evaluate the safety and efficacy of famciclovir for treating chronic hepatitis B.
  • To assess famciclovir's potential as an oral therapeutic option.

Main Methods:

  • Review of preclinical data.
  • Analysis of clinical data from a phase II dose-ranging study in immunocompetent patients.
  • Evaluation of data from liver transplant recipients in a compassionate use program.

Main Results:

  • Preclinical and clinical data suggest famciclovir is safe for oral treatment.
  • Evidence indicates famciclovir's potential efficacy in chronic hepatitis B.
  • The drug has been studied in both immunocompetent patients and transplant recipients.

Conclusions:

  • Famciclovir demonstrates promise for safe and convenient oral therapy in chronic hepatitis B.
  • Further investigation through phase III pivotal studies is warranted to confirm efficacy and safety.
  • Famciclovir may offer a valuable new treatment avenue for chronic hepatitis B.

Related Experiment Videos