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Health resource utilization associated with switching to risperidone long-acting injection.

C L Young1, D M Taylor

  • 1Pharmacy Department, Maudsley Hospital, London, UK.

Acta Psychiatrica Scandinavica
|June 16, 2006
PubMed
Summary
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Risperidone long-acting injection (RLAI) use was associated with increased hospital bed stay and healthcare resource utilization. This study found that switching to RLAI did not reduce hospitalization, contrary to expectations.

Area of Science:

  • Psychiatry
  • Pharmacoeconomics
  • Health Services Research

Background:

  • Oral antipsychotics and conventional depot formulations are known to reduce healthcare costs by decreasing hospitalizations.
  • The economic impact of newer long-acting injectable antipsychotics, such as risperidone long-acting injection (RLAI), on healthcare resource utilization requires further investigation.

Purpose of the Study:

  • To evaluate the effect of risperidone long-acting injection (RLAI) on hospital bed stay within a real-world clinical setting.
  • To assess changes in healthcare resource use following the initiation of RLAI.

Main Methods:

  • A retrospective study identified patients prescribed RLAI and tracked their resource use for 3 years prior to and 1 year after treatment initiation.
  • The primary outcome measure was the change in hospital bed stay before and after RLAI prescription.

Related Experiment Videos

  • Data were collected from 250 subjects, with 81 (32.4%) completing 1 year of treatment.

    • Main Results:

    • Hospital bed stay significantly increased after initiating RLAI, rising from 31 days (year -3) to 141 days (year +1) per patient.
    • Direct healthcare costs mirrored the increase in bed stay.
    • No significant difference in outcomes was observed between patients who continued RLAI and those who discontinued it.

    Conclusions:

    • The transition to risperidone long-acting injection (RLAI) was associated with a continued increase in hospital bed stay and healthcare resource utilization.
    • RLAI did not appear to reduce hospitalization or associated costs in this clinical practice setting.
    • Further research is needed to understand the factors influencing resource use with long-acting injectable antipsychotics.