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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Deep vein thrombosis outcome and the level of oral anticoagulation therapy

J A Caprini1, J I Arcelus, J J Reyna

  • 1Departments of Surgery, Evanston Northwestern Healthcare and Northwestern University Medical School, Evanson, Illinois, USA

Journal of Vascular Surgery
|November 5, 1999
PubMed

Insights

Maintaining a higher international normalized ratio (INR) during warfarin therapy improves deep vein thrombosis (DVT) resolution. Achieving therapeutic INR levels minimizes incomplete DVT resolution and chronic venous insufficiency symptoms.

Area of Science:

  • Vascular Medicine
  • Hematology
  • Thrombosis Research

Background:

  • Deep vein thrombosis (DVT) affects numerous patients, necessitating effective anticoagulation strategies.
  • Warfarin is a common oral anticoagulant, but optimal therapeutic ranges for DVT resolution require further investigation.

Purpose of the Study:

  • To evaluate the rate of deep vein thrombosis (DVT) resolution.
  • To assess DVT outcomes based on achieved international normalized ratio (INR) levels during warfarin therapy.

Main Methods:

  • A prospective study followed 33 patients (35 limbs) with acute symptomatic DVT for 1 year.
  • Patients received initial heparin followed by 6 months of warfarin targeting an INR of 2.0-3.0.
  • Venous duplex scanning and physical examinations were performed at multiple time points.

Main Results:

  • Complete DVT resolution occurred in 68% of patients over 1 year.
  • Higher median INR values correlated with complete DVT resolution at 1, 3, and 6 months.
  • Occlusive thrombi were linked to incomplete resolution and higher rates of chronic venous insufficiency.

Conclusions:

  • A significant proportion of DVTs remain unresolved despite 6 months of anticoagulation.
  • Maintaining INR levels between 2.0 and 3.0 appears crucial for optimizing DVT resolution.
  • Achieving and maintaining therapeutic INR levels may reduce the incidence of incomplete DVT resolution and subsequent complications.
Abstract

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