Chemotherapy of choroid plexus carcinoma

Choroid plexus carcinoma is a rare and frequently lethal tumor. Its cure depends primarily on the achievement of gross total resection. The contribution of adjuvant therapies, both irradiation and chemotherapy, in the context of gross total resection is unclear, but where such resection is not possible there may be a role for adjuvant therapy to permit more nearly complete resection. In particular, the limitation on resectability is imposed by the friability and extraordinary degree of vascularity, both of which may be favorably influenced by the use of chemotherapy following an initial biopsy, with deferral of the attempt at definitive resection until the impact of chemotherapy has been realized.